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Literature summary extracted from
- Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine (1997), Br. J. Clin. Pharmacol., 43, 245-252 .
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.55 | 2-naphthoflavone | 0.05 mM 2-naphthoflavone activates the enzyme (about 40%) in the presence of high substrate concentrations (0.5 mM) | Homo sapiens |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.55 | 2-naphthoflavone | 0.05 mM 2-naphthoflavone is inhibitory (about 60%) in the presence of low substrate concentrations (0.1 mM) | Homo sapiens | |
| 1.14.14.55 | erythromycin | about 45% inhibition at 0.01 mM | Homo sapiens | |
| 1.14.14.55 | midazolam | specific inhibitor, about 25% inhibition at 0.01 mM | Homo sapiens | |
| 1.14.14.55 | troleandomycin | about 95% inhibition at 0.01 mM | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.55 | 0.00083 | - |
Quinine | at pH 7.4 and 37°C | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.55 | microsome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.55 | quinine + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.55 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.55 | liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.55 | quinine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.55 | CYP3A | - |
Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.55 | 0.11 | - |
midazolam | at pH 7.4 and 37°C | Homo sapiens | |
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